I voted for Okami, as I think Cave Story's characters would have tons of detail, and the mimigas would probably look better.
Also, my thoughts on Cave Story 3D, I'm not going to Quote anybody because everyone has already said this, but I think the game looks fine in the state it's in, it is only meant to be a graphic remastering. Though I do think the game has a tendency to look like a poorly lighted PS2 game, and it made hate the game when I first got Cave Story 3D, but the game looks better when you're well . .. PLAYING it. The only thing that still rubs me the wrong way is the America art, but that's only because I prefer the Japanese art.